Topoisomerases - These are a group of enzymes that breaks, swivels, and rejoins the DNA strands to relieve the strain of supercoiling.
DNA gyrase - This is actually a type of topoisomerase found in prokaryotes. Its function is to create negative supercoils to relieve the strain caused by supercoiling.
Single-strand binding protein - when the DNA strands are unwound, then this protein keeps them from binding back together.
Helicase - This is the protein that binds to the DNA at the replication fork and unwinds it. It separates the two strands. It keeps moving down the replication fork.
DNA ligase - The protein is an enzyme that creates phophodiester linkages. So when replication is complete, it binds the okazaki fragments together to create one whole strand.
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